This thoroughly revised new edition of a classic book provides a clinically inspired but scientifically guided approach to the biological foundations of human mental function in health and disease. It includes authoritative coverage of all the major areas related to behavioral neurology, neuropsychology, and neuropsychiatry. Each chapter, written by a world-renowned expert in the relevant area, provides an introductory background as well as an up-to-date review of the most recent developments. Clinical relevance is emphasized but is placed in the context of cognitive neuroscience, basic neuroscience, and functional imaging. Major cognitive domains such as frontal lobe function, attention and neglect, memory, language, prosody, complex visual processing, and object identification are reviewed in detail. A comprehensive chapter on behavioral neuroanatomy provides a background for brain-behavior interactions in the cerebral cortex, limbic system, basal ganglia, thalamus, and cerebullum. Chapters on temperolimbic epilepsy, major psychiatric syndromes, and dementia provide in-depth analyses of these neurobehavioral entities and their neurobiological coordinates. Changes for this second edition include the reflection throughout the book of the new and flourishing alliance of behavioral neurology, neuropsychology, and neuropsychiatry with cognitive science;major revision of all chapters; new authorship of those on language and memory; and the inclusion of entirely new chapters on psychiatric syndromes and the dementias. Both as a textbook and a reference work, the second edition of Principles of Behavioral and Cognitive Neurology represents an invaluable resource for behavioral neurologists, neuropsychologists, neuropsychiatrists, cognitive and basic neuroscientists, geriatricians, physiatrists, and their students and trainees.

Contributors xvii
 Behavioral Neuroanatomy: Large-Scale 1 (120)
 Networks, Association Cortex, Frontal
 Syndromes, the Limbic System, and Hemispheric
 Specializations
 M.-Marsel Mesulam
 Introduction 1 (1)
 Parts of the Cerebral Cortex 2 (10)
 Cortical Organization, Connectivity, and 12 (5)
 Transmodal Areas
 Functions of Individual Cortical Zones: 17 (4)
 Primary Sensory and Motor Areas
 Functions of Modality-Specific (Unimodal) 21 (11)
 Sensory Association Areas
 Motor Association Areas (Premotor Cortex, 32 (2)
 Supplementary Motor Area, Frontal Eye
 Fields)
 Temporal Heteromodal Cortex and 34 (3)
 Agnosias---Transmodal Gateways for the
 Recognition of Faces, Objects, and Voices
 Wernicke's Area as a Temporoparietal 37 (2)
 Transmodal Gateway for Language
 Functions and Syndromes of Posterior 39 (2)
 Parietal Heteromodal Cortex
 Prefrontal Heteromodal Cortex and Frontal 41 (8)
 Lobe Syndromes: Attention, Executive
 Functions, and Comportment
 Paralimbic (Mesocortical) Areas 49 (6)
 Limbic Structures of the Septal Area, 55 (1)
 Nucleus Basalis, and Piriform Cortex
 The Amygdala, Emotion, and Affiliative 56 (3)
 Behaviors: Gateway into the Neurology of
 Value
 The Hippocampus and the Binding of 59 (5)
 Distributed Information into Explicit
 Memory: Gateway into the Neurology of
 Recollection
 The Limbic System 64 (2)
 Basal Ganglia and Cerebellum 66 (5)
 The Thalamus 71 (5)
 Channel Functions and State Functions 76 (4)
 Hemispheric Specialization and Asymmetry 80 (6)
 Distributed Large-Scale Networks and Their 86 (5)
 Cortical Epicenters
 Overview and Conclusions 91 (30)
 Neuropsychological Assessment of Mental State 121 (53)
 Sandra Weintraub
 Introduction: General Principles 121 (2)
 General Strategy for the Mental-State 123 (36)
 Examination and Review of Primary
 Neurocognitive Domains
 Testing the Elderly and the Diagnosis of 159 (3)
 Dementia
 Testing Lobes and Hemispheres 162 (2)
 Overview and Conclusions 164 (10)
 Attentional Networks, Confusional States, and 174 (83)
 Neglect Syndromes
 M.-Marsel Mesulam
 Introduction 174 (3)
 Confusional States as Disorders of the 177 (6)
 Attentional Matrix
 Biology of the Attentional Matrix 183 (10)
 Neglect Syndromes as Disorders of Spatial 193 (20)
 Attention
 Right Hemisphere Dominance for Spatial 213 (5)
 Attention
 Functional Anatomy of Unilateral Neglect 218 (14)
 Dissociations and Subtypes---Is There 232 (1)
 Parietal Versus Frontal Neglect?
 A Neural Network for the Distribution of 233 (3)
 Spatial Attention
 Overlap with Other Networks: Eye Movements, 236 (1)
 Working Memory, and Temporal Expectation
 Causes, Course, and Treatment of Unilateral 237 (1)
 Neglect and Relationship to Other
 Components of the Right Hemisphere Syndrome
 Overview and Conclusions 238 (19)
 Memory and Amnesia 257 (37)
 Hans J. Markowitsch
 Introduction 257 (1)
 The Classic Limbic Amnesic Syndrome 257 (5)
 Memory and Its Disorders 262 (4)
 The Anatomical Substrates of Memory 266 (12)
 Amnesia Syndromes 278 (4)
 Memory Rehabilitation 282 (1)
 Overview 283 (11)
 Aphasia and the Neural Basis of Language 294 (22)
 Antonio R. Damasio
 Hanna Damasio
 Introduction 294 (2)
 The Aphasias 296 (7)
 Language Impairments Following Damage 303 (2)
 Outside Classical Language Territories
 Sign Language Aphasia 305 (1)
 The Role of Nondominant Hemisphere Cortices 305 (1)
 in Language
 Aphasia Management 306 (1)
 Overview 307 (9)
 Affective Prosody and the Aprosodias 316 (16)
 Elliot D. Ross
 Introduction 316 (1)
 Neurology of Prosody 317 (1)
 Neurology of Kinesics 318 (1)
 The Aprosodias 319 (3)
 Clinical Examination of Affective Prosody 322 (1)
 and Gesture
 Hemispheric Lateralization of Affective 323 (2)
 Prosody and Callosal Integration of
 Language Functions
 Aprosodias in Tone Languages 325 (1)
 Aprosodias, Display Behaviors, and 326 (6)
 Emotional Experience
 Disorders of Complex Visual Processing 332 (41)
 Antonio R. Damasio
 Daniel Tranel
 Matthew Rizzo
 Disorders of Pattern Recognition 332 (7)
 Other Disorders of Face Processing 339 (7)
 Disorders of Color Perception 346 (5)
 Other Disorders Related to Color Processing 351 (2)
 Disorders of Spatial Analysis 353 (9)
 Disturbances of Constructional Ability 362 (1)
 Disturbance of the Ability to Dress 363 (1)
 Concluding Remarks 363 (10)
 Temporolimbic Epilepsy and Behavior 373 (33)
 Donald L. Schomer
 Margaret O'Connor
 Paul Spiers
 Margitta Seeck
 M.-Marsel Mesulam
 David Bear
 Introduction 373 (1)
 Classification and Definition 374 (1)
 Anatomical Pathophysiology 375 (2)
 Ictal Manifestations of TLE 377 (6)
 Interictal (Long-Term) Associations of TLE 383 (6)
 The Diagnostic Evaluation and workup 389 (2)
 Treatment 391 (6)
 Overview 397 (9)
 Neural Substrates of Psychiatric Syndromes 406 (33)
 Robert M. Post
 Introduction 406 (4)
 Unipolar and Bipolar Affective Disorders 410 (7)
 Anxiety-Related Disorders 417 (6)
 Schizophrenia 423 (2)
 Austism 425 (1)
 Overview 426 (13)
 Aging, Alzheimer's Disease, and Dementia: 439 (84)
 Clinical and Neurobiological Perspectives
 M.-Marsel Mesulam
 Introduction 439 (1)
 Aging and the Human Brain 440 (4)
 The Definition and Differential Diagnosis 444 (8)
 of Dementia
 Some Clinical Profiles of Behaviorally 452 (9)
 Focal Primary Dementias
 Alzheimer's Disease---Genetics, Clinical 461 (8)
 Picture, and Diagnosis
 The Neuropathology of AD 469 (17)
 Plasticity Failure---A Hypothesis for 486 (7)
 Unifying the Pathogenesis of Plaques and
 Tangles
 Some Non-AD Dementias 493 (8)
 Vascular Dementia [Also Known as 501 (3)
 Multiinfarct Dementia (MID)]
 Patient Care and Treatment in AD and Other 504 (2)
 Dementias
 Overview and Conclusions 506 (17)
 Index 523